

About Us
The Hill Lab is housed in the Department of Biology at the University of York. We're also part of the York Structural Biology Laboratory and the York Biomedical Research Institute
Our Team
We're a group of friendly and supportive scientists interested in proteins, RNA, ribosomes, translational regulation and the control of virus gene expression. The Hill lab is an inclusive, international space where diversity is celebrated.

Principal Investigator
Chris H. Hill
Chris is a structural and molecular biologist with a background in X-ray crystallography, cryo-EM and RNA biology. He's interested in the regulation of viral gene expression - particularly in how RNA viruses 'break the rules' when they execute their own genetic code.

Postdoctoral Research Associate
Tim C. Passchier
Tim is originally from the Netherlands and joins us as a Wellcome-funded postdoctoral research associate with a broad background in structural and molecular virology gained at the Universities of Utrecht, Oxford, and Leeds. In the Hill lab he will be investigating virus-induced ribosomal recoding through structural and molecular approaches.

PhD student
Miguel Aracena Velazquez
Miguel is originally from Bolivia, but has lived most of his life abroad. He has a background in Biochemistry, and industry experience from his time at Oxford Nanopore Technologies. He is very excited to join the Hill Lab to begin his PhD project on investigating the structural and mechanistic basis of translation initiation in enteroviruses. Miguel is supported by the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology.

PhD student
Jemma Betts
Jemma has a background in structural and molecular protein biochemistry. After working at UCL studying the structures of infectious prions, Jemma is very excited to join the Hill lab and begin her PhD, investigating RNA-protein interactions that stimulate programmed ribosomal frameshifting during viral infection. She is enthusiastic to apply her experience with cryo-EM to her PhD project. Jemma is supported by the MRC DiMeN Doctoral Training Program.

Visiting Associate
Lewis Chan
Lewis joined us in 2024/5 to work on ribosomes in collaboration with Sergey Melnikov's group at the University of Newcastle. He uses cryo-electron microscopy to understand how various bacteria preserve their vital machinery such as ribosomes during conditions of stress.

Visiting Associate
Karla Helena Bueno
Karla joined us in 2022/23 as part of a collaboration with Sergey Melnikov's group. Originally from the Dominican Republic, Karla has a background in microbiology from her studies at Michigan State University. She earned her PhD from Newcastle University, where she investigates the molecular mechanisms of ribosome hibernation in bacteria.
Alumni

Summer Student
Ashleigh Smith
Ashleigh joined us for a summer project in 2022 through the Generation Research scheme. She now works for RSSL as a Biomolecular Analysis Senior Technician.

Research Technician
Catherine Cockeram
Cath joined us in 2022 as a founding member of the lab. With a background in genetics, microbiology and immunology, she's interested in studying processes used by pathogens to interact with and exploit host cells. Cath left our group in October 2024 to start a PhD with Dr Anton Calabrese at the University of Leeds.

Masters Student
Luke Corbett
Luke joined us for the 2023-2024 academic year as a 4th year Masters student. In collaboration with the McGonigal Group, he used X-ray crystallography and enzyme kinetics to investigate the protein-binding capacity of novel shapeshifting compounds.
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Summer Student
Alex Whitaker
Alex joined us in 2024 for a Generation Research summer project supervised by Miguel, investigating whether the EMCV 2A protein differentially affects host and virus mRNA translation. He previously worked at The Pirbright Institute applying CRISPR/Cas9 to attempt to improve vaccines against Marek's Disease Virus. Alex is now in the final year of his Masters degree.
Our Facilities
We benefit from direct access to state-of-the art core equipment in the Biosciences Technology Facility and the adjacent Eleanor and Guy Dodson Building in the York Structural Biology Laboratory

Cryo-EM / TEM
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2x FEI Vitrobot
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Glow discharger, plasma cleaner and carbon evaporator
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200 kV Glacios with Falcon IV
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Tecnai Spirit T12 with Ceta
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Viking 2 compute cluster: 12,864 CPU cores and 60 GPUs
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Frequent access to Krios microscopes through eBIC BAG

X-ray crystallography
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Mosquito and Oryx robots
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Automated crystal plate imaging robot
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Rigaku XtaLAB Synergy-R diffractometer
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Automatic cryo sample changer
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Frequent access to Diamond Light Source through BAG

Imaging and cytometry
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Zeiss Elyra 7 with SIM2
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Zeiss LSM 880 with Airyscan
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Zeiss LSM 780 multiphoton
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Zeiss LSM 710
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Zeiss LSM 510 META
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Four-colour custom TIRF imaging
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LUMICKS C-Trap optical tweezers

Molecular interactions
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smFRET (EI-FLEX)
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Mass photometry (Refeyn)
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Isothermal Titration Calorimetry
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Surface Plasmon Resonance
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SEC-MALS
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Microscale Thermophoresis
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Differential Scanning Fluorimetry
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Circular Dichroism Spectroscopy

Protein and RNA purification
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AKTA Pure FPLC with triple wavelength detector, multi-inlet, and sample loading pump
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Sucrose gradient maker and fractionator
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E.coli, baculovirus and mammalian expression platforms
Our Funding



